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GLP-1 (semaglutide or tirzepatide) Therapy in Older Adults: Balancing Benefit & Risk Beyond Age 65 Joshua Silva, MD Dec 12, 2025 4 min read Medically authored by Joshua Silva, MD | Evidence-Based Weight Loss at Potere Health MD Last clinically updated: December 2025 Many discussions about GLP-1 medications in older adults come from friends, family, or acquaintances , as well as online forums, news stories, and social media posts

Animal research has shown issues like reduced fetal growth and developmental changes when GLP-1 medications were used during pregnancy, which is why experts advise using reliable contraception while on treatment and stopping early when planning for pregnancy

Create a checklist for fertility docs and clinics to ensure safe and effective integration of GLP-1s into fertility treatment regimens Checklist: baseline pregnancy test, informed consent covering side effects and intra-uterine/fetal data, metabolic and reproductive labs, schedule for combination therapy if applicable, monthly pregnancy testing schedule, discontinue GLP-1 two months prior to trying to conceive or stimulation pause weeks prior to surgeries under anesthesia, continued weight and hormone follow-up, contingency for potential side effects, patient education materials

Are there any side effects associated with GLP-1 medications

The absence of blend-level human data is not a technicality to route around it is the central fact about KLOWs status

The patient stays sick longer